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PHOSPHATIDYLCHOLINE-STEROL O-ACYLTRANSFERASE
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DeCS
Descriptor
English
:
Phosphatidylcholine-Sterol O-Acyltransferase
Descriptor
Spanish
:
Fosfatidilcolina-Esterol O-Aciltransferasa
Descriptor
Portuguese
:
Fosfatidilcolina-Esterol O-Aciltransferase
Synonyms
English
:
Lecithin Cholesterol Acyltransferase
Lecithin Acyltransferase
Tree Number:
D08.811.913.050.625
Definition
English
:
An enzyme secreted from the liver into the
plasma
of many mammalian species. It catalyzes the
esterification
of the hydroxyl group of lipoprotein
cholesterol
by the transfer of a fatty acid from the C-2 position of lecithin. In familial lecithin:
cholesterol
acyltransferase deficiency
disease
, the absence of the enzyme results in an excess of unesterified
cholesterol
in
plasma
. EC 2.3.1.43.
Entry Combination - descr/qualif
English
:
Phosphatidylcholine-Sterol O-Acyltransferase
/
deficiency
use
Lecithin Acyltransferase Deficiency
History Note
English
:
98(75)
Allowable Qualifiers
English
:
AD
administration & dosage
AE
adverse effects
AN
analysis
AI
antagonists & inhibitors
BI
biosynthesis
BL
blood
CF
cerebrospinal fluid
CS
chemical synthesis
CH
chemistry
CL
classification
CT
contraindications
DE
drug effects
EC
economics
GE
genetics
HI
history
IM
immunology
IP
isolation & purification
ME
metabolism
PK
pharmacokinetics
PD
pharmacology
PH
physiology
PO
poisoning
RE
radiation effects
SE
secretion
ST
standards
SD
supply & distribution
TU
therapeutic use
TO
toxicity
UL
ultrastructure
UR
urine
Record Number:
8040
Unique Identifier:
D007862
Occurrence in VHL
:
Similar:
DeCS
CID-10
SciELO
LILACS
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